Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC058
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-03 15:52
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Le3vo dopa 1\2,1\4, 1\2,1\4 caps Madopar HBS 125mg 2x1 old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 19 individuals with a value less than 0.57 were subsequently diagnosed with PD. That is, 45.24% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.57 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 11, 'TN': 10, 'TP': 31, 'FP': 20}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 10, 'TN': 11, 'TP': 32, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 41, 'TN': 30, 'TP': 1, 'FP': 0}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 27.736
timePerCircleCoV 0.265618
timePerCircleSlope -0.0370069
meanError 2.73646
tremorFreq 6.25
tremorRelPower 27.0429
tremorGyroAmpMean 0.0283932
tremorGyroAmpSlope 0.00160227
tremorGyroAmpCoV 0.575589
tremorCoordAmpMean 0.0331102
tremorCoordAmpSlope 0.00113995
tremorCoordAmpCoV 0.43717
tremorAccAmpMean 0.0756139
tremorAccAmpSlope 0.000168494
tremorAccAmpCoV 0.0923875
tremorPcRelVar 0.634288
tremorPcX 0.507851
tremorPcY 0.861445

Circle Segment 1

Duration 27.88 s, Accuracy Estimate 1.555 (lower is better)

Circle Segment 2

Duration 33.0 s, Accuracy Estimate 1.946 (lower is better)

Circle Segment 3

Duration 36.28 s, Accuracy Estimate 3.516 (lower is better)

Circle Segment 4

Duration 23.36 s, Accuracy Estimate 1.654 (lower is better)

Circle Segment 5

Duration 38.0 s, Accuracy Estimate 3.096 (lower is better)

Circle Segment 6

Duration 16.8 s, Accuracy Estimate 1.41 (lower is better)

Circle Segment 7

Duration 30.12 s, Accuracy Estimate 4.082 (lower is better)

Circle Segment 8

Duration 22.32 s, Accuracy Estimate 1.757 (lower is better)

Circle Segment 9

Duration 31.56 s, Accuracy Estimate 5.453 (lower is better)

Circle Segment 10

Duration 18.04 s, Accuracy Estimate 2.893 (lower is better)

Spiral

numSpirals 2
timePerSpiralMean 79.64
timePerSpiralCoV 0.00639273
timePerSpiralSlope -0.00904068
meanError 2.32428
tremorFreq 5.07812
tremorRelPower 34.8797
tremorGyroAmpMean 0.0373141
tremorGyroAmpSlope 0.00353003
tremorGyroAmpCoV 0.496407
tremorCoordAmpMean 0.0490212
tremorCoordAmpSlope 0.00179412
tremorCoordAmpCoV 0.352091
tremorAccAmpMean 0.044973
tremorAccAmpSlope 0.00216517
tremorAccAmpCoV 0.425761
tremorPcRelVar 0.688843
tremorPcX -0.549653
tremorPcY -0.835393

Spiral Segment 1

Duration 80.0 s, Accuracy Estimate 2.433 (lower is better)

Spiral Segment 2

Duration 79.28 s, Accuracy Estimate 2.216 (lower is better)

Elel

eDurationMean 0.795732
eDurationStd 0.244409
eDurationStdnorm 0.30715
eDurationMedian 0.765
eDurationQuartdelta 0.29375
eDurationQuartdeltanorm 0.383987
eDurationKurt 5.71719
eDurationTrenddiff -0.05
eDurationTrendratio 0.93808
eWidthMean 3.7868
eWidthStd 0.948262
eWidthStdnorm 0.250412
eWidthMedian 3.627
eWidthQuartdelta 0.936
eWidthQuartdeltanorm 0.258065
eWidthKurt 3.81178
eWidthTrenddiff 0.4095
eWidthTrendratio 1.11864
eHeightMean 8.85205
eHeightStd 2.91464
eHeightStdnorm 0.329262
eHeightMedian 8.541
eHeightQuartdelta 2.13525
eHeightQuartdeltanorm 0.25
eHeightKurt 12.5987
eHeightTrenddiff 1.2285
eHeightTrendratio 1.15789
eAspectMean 0.440512
eAspectStd 0.0893046
eAspectStdnorm 0.202729
eAspectMedian 0.426829
eAspectQuartdelta 0.115473
eAspectQuartdeltanorm 0.270538
eAspectKurt 2.37685
eAspectTrenddiff -0.0581531
eAspectTrendratio 0.874635
eSlantMean -0.0659122
eSlantStd 0.163973
eSlantStdnorm -2.48775
eSlantMedian -0.0731707
eSlantQuartdelta 0.253857
eSlantQuartdeltanorm -3.46938
eSlantKurt 2.09374
eSlantTrenddiff 0.160081
eRtopMean 0.611676
eRtopStd 0.126958
eRtopStdnorm 0.207557
eRtopMedian 0.62069
eRtopQuartdelta 0.152473
eRtopQuartdeltanorm 0.24565
eRtopKurt 2.71617
eRtopTrenddiff 0.0925185
eRbotMean 0.79563
eRbotStd 0.340922
eRbotStdnorm 0.428494
eRbotMedian 0.769231
eRbotQuartdelta 0.580383
eRbotQuartdeltanorm 0.754498
eRbotKurt 2.34753
eRbotTrenddiff -0.146087
eRrightMean 0.806445
eRrightStd 0.087609
eRrightStdnorm 0.108636
eRrightMedian 0.823529
eRrightQuartdelta 0.080861
eRrightQuartdeltanorm 0.0981884
eRrightKurt 3.22748
eRrightTrenddiff 9.50893e-05
eRleftMean 0.418344
eRleftStd 0.140327
eRleftStdnorm 0.335435
eRleftMedian 0.428571
eRleftQuartdelta 0.209679
eRleftQuartdeltanorm 0.489251
eRleftKurt 2.32018
eRleftTrenddiff -0.0660605
lDurationMean 1.14714
lDurationStd 0.312057
lDurationStdnorm 0.27203
lDurationMedian 1.18
lDurationQuartdelta 0.45
lDurationQuartdeltanorm 0.381356
lDurationKurt 2.41344
lDurationTrenddiff -0.12
lDurationTrendratio 0.905882
lWidthMean 4.55966
lWidthStd 1.24388
lWidthStdnorm 0.272802
lWidthMedian 4.095
lWidthQuartdelta 1.8135
lWidthQuartdeltanorm 0.442857
lWidthKurt 2.14092
lWidthTrenddiff 0.234
lWidthTrendratio 1.05714
lHeightMean 19.7195
lHeightStd 2.36164
lHeightStdnorm 0.119761
lHeightMedian 20.007
lHeightQuartdelta 2.60325
lHeightQuartdeltanorm 0.130117
lHeightKurt 3.07413
lHeightTrenddiff 0.234
lHeightTrendratio 1.01176
lAspectMean 0.231314
lAspectStd 0.0552928
lAspectStdnorm 0.239038
lAspectMedian 0.227027
lAspectQuartdelta 0.0830912
lAspectQuartdeltanorm 0.365997
lAspectKurt 2.43738
lAspectTrenddiff 0.0113836
lAspectTrendratio 1.05014
lSlantMean 0.0280813
lSlantStd 0.0822663
lSlantStdnorm 2.92958
lSlantMedian 0.0350877
lSlantQuartdelta 0.090322
lSlantQuartdeltanorm 2.57418
lSlantKurt 3.86884
lSlantTrenddiff 0.0122096
lRtopMean 0.709587
lRtopStd 0.126564
lRtopStdnorm 0.178363
lRtopMedian 0.724138
lRtopQuartdelta 0.19704
lRtopQuartdeltanorm 0.272103
lRtopKurt 3.40954
lRtopTrenddiff 0.0031348
lRbotMean 0.634712
lRbotStd 0.283627
lRbotStdnorm 0.446859
lRbotMedian 0.581395
lRbotQuartdelta 0.317577
lRbotQuartdeltanorm 0.546232
lRbotKurt 3.51539
lRbotTrenddiff -0.0678818
lRrightMean 0.863624
lRrightStd 0.0534849
lRrightStdnorm 0.0619308
lRrightMedian 0.857143
lRrightQuartdelta 0.0693886
lRrightQuartdeltanorm 0.0809533
lRrightKurt 2.86371
lRrightTrenddiff -0.0126205
lRleftMean 0.285214
lRleftStd 0.160372
lRleftStdnorm 0.562286
lRleftMedian 0.258824
lRleftQuartdelta 0.193915
lRleftQuartdeltanorm 0.749216
lRleftKurt 4.23089
lRleftTrenddiff -0.0266715

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

Elel Segment 15

FITTS Short Modified

meanTouchScore 0.930688
sumTouchScores 13.0296
meanMovementTime 1.27462
numTouches 14
undershootPercentage 0
overshootPercentage 7.14286

FITTS Long Modified

meanTouchScore 0.852787
sumTouchScores 11.0862
meanMovementTime 1.33667
numTouches 13
undershootPercentage 7.69231
overshootPercentage 23.0769

ZigZag

numZigzags 4
timePerZigzagMean 72.43
timePerZigzagCoV 0.105035
timePerZigzagSlope -0.00358967
meanError 2.15893
tremorFreq 5.37109
tremorRelPower 27.7063
tremorGyroAmpMean 0.0364375
tremorGyroAmpSlope 0.000917254
tremorGyroAmpCoV 0.562148
tremorCoordAmpMean 0.0552412
tremorCoordAmpSlope 0.000864382
tremorCoordAmpCoV 0.467041
tremorAccAmpMean 0.0492126
tremorAccAmpSlope 0.00028457
tremorAccAmpCoV 0.482188
tremorPcRelVar 0.771494
tremorPcX -0.220876
tremorPcY 0.975302

ZigZag Segment 1

Duration 66.56 s, Accuracy Estimate 2.209 (lower is better)

ZigZag Segment 2

Duration 78.24 s, Accuracy Estimate 1.91 (lower is better)

ZigZag Segment 3

Duration 79.72 s, Accuracy Estimate 2.384 (lower is better)

ZigZag Segment 4

Duration 65.2 s, Accuracy Estimate 2.132 (lower is better)

ZigZag Offset

numZigzags 4
timePerZigzagMean 29.35
timePerZigzagCoV 0.147115
timePerZigzagSlope -0.0434753
zigzagHeightMean 62.1593
zigzagHeightCoV 0.101732
zigzagHeightSlope 0.0652655
meanError 0.10123
tremorFreq 6.83594
tremorRelPower 23.6243
tremorGyroAmpMean 0.022938
tremorGyroAmpSlope -0.000491258
tremorGyroAmpCoV 0.414291
tremorCoordAmpMean 0.0407175
tremorCoordAmpSlope 0.00133914
tremorCoordAmpCoV 0.36187
tremorAccAmpMean 0.0267366
tremorAccAmpSlope 0.000757705
tremorAccAmpCoV 0.413146
tremorPcRelVar 0.72383
tremorPcX -0.396016
tremorPcY 0.918244

ZigZag Offset Segment 1

Duration 34.08 s, Accuracy Estimate 0.086 (lower is better)

ZigZag Offset Segment 2

Duration 28.12 s, Accuracy Estimate 0.061 (lower is better)

ZigZag Offset Segment 3

Duration 24.0 s, Accuracy Estimate 0.144 (lower is better)

ZigZag Offset Segment 4

Duration 31.2 s, Accuracy Estimate 0.113 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.88}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.57}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.3909705954806333}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8726314256971011}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7312142615073438}